Results: In the present study, we demonstrate that some neuroblastoma cell lines are actually resistant to bortezomib.
We have sought to characterize the main pathway by which proteasome inhibition leads to apoptosis, and to define the mechanism responsible for resistance to bortezomib in neuroblastoma cells. Our results show that SB202190, an inhibitor of mitogen-activated protein kinase (MAPK) p38, enhances the ability of bortezomib to induce apoptosis by preventing the phosphorylation of the heat shock protein (HSP) 27.
Conclusion: This study opens the way to further clinical investigations and suggests a potential benefit of using a combination of bortezomib with an inhibitor of p38 MAPK for the treatment of neuroblastoma relapse.
Author: Valerie Combaret, Sandrine Boyault, Isabelle Iacono, Stephanie Brejon, Raphael Rousseau and Alain Puisieux
Credits/Source: Molecular Cancer 2008, 7:50
Published on: 2008-06-05
